Specialized Assays |
Biobehavioral Oncology Facility, at UPMC Hillmann Cancer Center | Frank Jenkins |
The Biobehavioral Oncology Facility at UPMC Hillman Cancer Center provides wet lab support for specimen processing and a wide range of assays for biobehavioral researchers lacking access to wet lab space and/or necessary expertise. Location: Shadyside, HCC |
Cancer Pharmacokinetics and Pharmacodynamics Facility, UPMC Hillman Cancer Center | Robert Parise, PhD |
The UPMC Hillman Cancer Center Cancer Pharmacokinetics and Pharmacodynamics Facility provides accessible, economical, comprehensive, and state-of-the-art bioanalytical, pharmacokinetic and pharmacology research services that support preclinical and clinical research programs focused on oncology at UPMC Hillman Cancer Center and medical institutions nationwide. Resources include HPLC-UV/fluorescence, ICP-MS, LC-MS/MS, LSC, ELISA, and in vivo rodent procedures, as well as advanced PK software suites and expertise for preclinical and clinical projects. Location: Shadyside, HCC |
CRISMA Clinical Research Biospecimen Core | Kelly Urbanek or Ali Smith-Scott |
CRISMA Clinical Research Biospecimen Core: The CRISMA Clinical Research and Biospecimen Core Laboratory (CRBC Lab) offers in a range of biomarker/analyte quantification services utilizing various platforms – Luminex, ELLA, and ELISA. In addition, the lab can isolate and quantify DNA from whole blood samples. The CRBC Lab technicians have extensive experience supporting multiple projects from multicenter NIH-funded clinical trials to pilot studies. Location: Oakland, SCAIF |
Luminex Core Laboratory, UPMC Hillman Cancer Center | Denise Prosser |
The Luminex Core Laboratory at UPMC Hillman Cancer Center performs assays using multiplexed, bead-based immunochemistry on minimal sample volumes. Luminex technology provides a method for profiling of up to 100 different proteins, peptides, or DNA molecules in a single microtiter well. Results have strong concordance to ELISA and mass spectrometry. Thousands of commercially validated kits are available for purchase through the core laboratory. A list of these assays can be requested.
Location: Shadyside, HCC |
Metabolic Core at John G. Rangos Sr. Research Center | Clinton Van't Land |
The Metabolic Core at John G. Rangos Sr. Research Center provides Instrument Services for analysis of 1) endogenous metabolic pathway intermediates or biomarkers from biological fluids, cell cultures, and tissues using liquid chromatography tandem mass spectrometry (LC-MS/MS), 2) energy metabolism (cell bioenergetics) in living cells using a Seahorse Analyzer to measure oxygen consumption rates (OCR) and/or extracellular acidification rates (ECAR), and 3) biomarkers/metabolites to quantitate pathway intermediates using HPLC with 3 detector options (ECD, UV-VIS, FLR). Location: Lawrenceville, RANCH |
Small Molecule Biomarker Core | Raymond West |
The Small Biomarker Core provides accurate and sensitive quantitative analysis in biological samples, with or without sample processing, using state-of-the-art ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). In addition to well qualified assays for common targets, experienced, knowledgeable personnel can provide assay development for novel targets Location: Oakland, SALKP |